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Skillet Cajun Chicken Pasta

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This skillet Cajun chicken pasta is full of flavor! Cajun seasoned chicken, bell peppers, mushrooms and tomatoes tossed with fettuccine in a cream sauce!
Course Mains & Entrees
Cuisine American
Keyword cajun, chicken, pasta, skillet
Prep Time 20 minutes
Cook Time 25 minutes
Total Time 45 minutes
Servings 6 servings
Calories 508
Author Laurie McNamara


  • pounds boneless skinless chicken breasts
  • tablespoons Cajun seasoning
  • 1 tablespoons olive oil more or less as needed
  • 1 small yellow onion sliced vertically into thin strips
  • 8 ounces mushrooms halved or quartered if large
  • 1/2 yellow bell pepper sliced (about 1/2 cup)
  • 1/2 orange bell pepper sliced (about 1/2 cup)
  • 3 cloves garlic minced
  • 1/3 cup dry white wine I use Sauvignon Blanc or chicken broth may be substituted
  • 2 medium Roma tomatoes seeded and diced
  • 3/4 cup heavy cream
  • 3/4 cup whole milk
  • 3/4 pound fettuccine noodles
  • kosher salt to taste
  • freshly ground black pepper to taste
  • parsley minced for garnish


  • Bring a large pot of water to boil.
  • Season the chicken pieces with 1-1/2 tablespoons of the Cajun seasoning.
  • Heat a large 12-inch skillet with a few tablespoons of olive oil over medium-high heat. Once hot, place the seasoned chicken in an even layer in the pan. Cook for 4-5 minutes before turning. Repeat for another 4-5 minutes or until the chicken is fully cooked. Remove the chicken to a clean plate.
  • Drop the pasta into the waiting boiling water and add in a tablespoon of sea salt. Follow package directions to cook the pasta al dente.
  • Add a teaspoon more of olive oil to the pan if needed and add in the onions, mushrooms and bell pepper. Cook for 5-6 minutes or until they are soft yet still a bit firm.
  • Add in the in the garlic and cook for 1 minute before pouring in the wine. Use a wooden spoon to scrape up the browned bits on the bottom of the pan and cook for 1 minute.
  • Next add in the tomatoes, heavy cream and whole milk. Stir, bringing this to a bubble until it has thickened a bit. Drain and add in the cooked pasta and also the Cajun chicken. Toss together and taste, seasoning with more salt and pepper as needed.
  • Serve with a little chopped parsley on top and enjoy!


Serving: 1g | Calories: 508kcal | Carbohydrates: 49g | Protein: 32g | Fat: 20g | Saturated Fat: 9g | Polyunsaturated Fat: 2g | Monounsaturated Fat: 7g | Trans Fat: 1g | Cholesterol: 152mg | Sodium: 152mg | Potassium: 834mg | Fiber: 4g | Sugar: 5g | Vitamin A: 1915IU | Vitamin C: 37mg | Calcium: 94mg | Iron: 2mg